No brainer - fantrax. Ridiculous customizability, and all their "automation" features saves huge amounts of time for the commissioner. I can't think of why anyone would use any other site unless they haven't heard of fantrax.
Hope that helps
League info: 15 team H-2-H
9 Forwards, 4 Defense, 2 Goalies
SKATERS: Goals, Assists, Shoot-out Goals, Powerplay Points, Shorthanded Points (X2), Penalty Minutes (X0.25)
GOALIES: Wins (X2), Shutouts (X3), Shootout Win, Penalty Minutes (X0.25)
PRO TEAM FORWARDS: Couture, Kucherov, Ovechkin, Schwartz, Tavares, Wennberg, J.T. Miller, Nugent-Hopkins, Spooner
PRO TEAM DEFENSE: Hedman, Pietrangelo, Trouba
PRO TEAM GOALIE: Johnson and Ward
MINOR TEAM FORWARDS: Larkin, Marner, Pasternak, Reinhart, Lazar, Lehkonen, McCann, Motte
MINOR TEAM DEFENSE: Chychrun, Deangelo, Matheson
MINOR TEAM GOALIE: Lehner, Saros, Vasilevskiy, Gillies and Sorokin
PROTECT 8 PROS AND 10 MINORS, can dress minors in weekly H-2-H matchups