Just heard on the radio that McCoy has a torn MCL and is "week to week". But with the Bills out of contention, I imagine it's safe to assume he's done for the year.

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...or I could have just checked rotoworld, which apparently reported the same thing (per Adam Schefter) about an hour ago.

http://www.rotoworld.com/player/nfl/5168/lesean-mccoy